SOUTH AFRICAN HEALTH PRODUCTS REGULATORY AUTHORITY (SAHPRA) Medicine Registration Officer: Clinical Preregistration Evaluation (1-Year Contract) Vacancy 2026 | Salary: R562,800 – R681,300 p.a.

Opportunity Overview

The South African Health Products Regulatory Authority (SAHPRA) is the national body responsible for monitoring, evaluating, regulating, investigating, inspecting, registering, and controlling medicines, scheduled substances, clinical trials, and medical devices in the public interest.

SAHPRA is seeking a dedicated Medicine Registration Officer for a 1-year contract role in Clinical Preregistration Evaluation. This position plays a critical part in ensuring the safety, quality, and efficacy of health products in South Africa, contributing directly to public health outcomes.

Minimum Requirements

• A matric certificate.
• A 4-year degree in Pharmacy or a 4-year degree in a Health-Sciences-related field (NQF Level 8) as recognised by the South African Qualification Framework (SAQA).
• Registration with the South African Pharmacy Council (SAPC) where applicable.
• A minimum of three (3) years' relevant post-internship experience.
• Knowledge and application of the Medicines and Related Substances Act No. 101 of 1965 as amended, and its related Regulations, concerning medicine regulation.
• Knowledge of the technical aspects and evaluation processes related to the quality, efficacy, and bioequivalence of medicines.
• Comprehensive knowledge and understanding of relevant legislation, regulatory guidelines, protocols, standard operating procedures (SOPs), and work instructions applicable to SAHPRA’s regulatory environment.

Key Responsibilities

• Evaluate new applications and conduct peer-reviewing of new applications/variations.
• Produce evaluation reports for new applications, ensuring compliance with prescribed templates and existing regulatory/scientific standards.
• Evaluate Type I and II applications for clinical or quality variation.
• Follow the peer-review process, amend reports, and generate queries for applicants using prescribed templates.
• Review other evaluators’ reports according to prescribed templates and accepted regulatory/scientific standards.
• Evaluate PI/PIL applications (new applications and responses).
• Prepare queries or feedback to applicants, including approval or rejection letters.
• Evaluate applicant responses for the registration/approval of medicines.
• Develop and update existing guidelines, Standard Operating Procedures (SOPs), and templates.
• Train new Medicine Registration Officers (MROs) and external evaluators.
• Attend workshops related to the latest guidelines, SOPs, and templates.
• Develop new guidelines, SOPs, and templates where applicable.
• Submit work plans and targets.

How to Apply

To apply for this opportunity, please visit the SAHPRA vacancies page:

• Application Portal: https://www.sahpra.org.za/vacancies
• Reference Number: SAHPRA 24 of 2026/27
• Location: Pretoria
• Closing Date: 23 July 2026